Currently, Plesa’s work primarily focuses on large-scale gene synthesis, which plays an important role in functional characterization of DNA sequences and for the development of synthetic biology. Current efforts in this area are slowed by their high cost.

Plesa developed a method called DropSynth, which allows the generation of large libraries of thousands of genes and functional testing of all possible mutations at relatively low cost. This opens many new avenues of research and potential applications previously deemed too expensive.