Chemistry elements
Chemistry and Biochemistry
Profile picture of Victoria DeRose

Victoria DeRose

Department Head
Professor
Chemistry and Biochemistry
derose@uoregon.edu
Phone: 541-346-3568
Office: 355A Klamath Hall
Research Interests: Bioinorganic Chemistry, Chemical Biology
Website: http://blogs.uoregon.edu/deroselab/

Research

We investigate the interactions of metals in biological systems, with emphasis on nucleic acids. This interdisciplinary research area combines chemical biology, bioinorganic chemistry, and biophysical chemistry.  Research topics include understanding how metal compounds, including anticancer agents, interact with cellular RNAs. To advance this unexplored area, we are engaged in developing novel and high-throughput methods and reagents for measuring in-cell platinum adducts and their biological consequences. In recent work we have synthesized a suite of new Pt(II) compounds modified for click-chemistry that enable post-treatment detection, including imaging bound Pt in mammalian cell culture and enriching for Pt-bound targets for downstream analysis. Another current direction is to understand the surprising specificity of certain Pt compounds to influence the nucleolus, the site of ribosome biogenesis and 'Achilles heel' of a growing cell.  Our laboratory team is interdisciplinary and inclusive, and we welcome a range of backgrounds including synthetic, biological, inorganic, and analytical chemistry.

Publications

https://scholar.google.com/citations?hl=en&user=-kJ8YCUAAAAJ&view_op=list_works&sortby=pubdate

Selected:

Pigg, H.C., Yglesias, M.V., Sutton, E.C., McDevitt, C.E., Shaw, *M., DeRose, V.J. Time-dependent studies of oxaliplatin and other nucleolar stress-inducting platinum compounds. ACS Chem. Biol. 2022, 17, 2262-2271. DOI: 10.1021/acschembio.2c00399.https://pubs.acs.org/doi/full/10.1021/acschembio.2c00399

*McDevitt, C.E., *Guerrero, A.S., Smith, H.M., DeRose V.J. Influence of ring modifications on nucleolar stress caused by oxaliplatin-like compounds. ChemBioChem, 2022, e20220013, (Very Important Paper designation); DOI:10.1002/cbic.202200130. https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cbic.202200130

Hunsicker-Wang, L.M., Vogt, M.J., Hoogstraten, C.F., Cosper, N.J., Davenport, A.M., Hendon, C.H., Scott, R.A., Britt, R.D., DeRose, V.J. Spectroscopic characterization of Mn2+ and Cd2+ coordination to phosphorothioates in the conserved A9 metal site of the hammerhead ribozyme. J. Inorg. Biochem. (Special issue in honor of Richard Holm) 2022, 230, 111754-111767. DOI 10.1016/j.jinorgbio.2022.111754

Sutton, E.C. and DeRose, V.J. Early nucleolar responses differentiate mechanisms of cell death induced by oxaliplatin and cisplatin. J. Biol. Chem. 296, 2021.  DOI 10.1016/j.jbc.2021.100633. https://www.sciencedirect.com/science/article/pii/S0021925821004191?via%3Dihub

Yglesias, M.V. and DeRose, V.J. ‘Metal ion interactions with DNA, RNA, and ribozymes’ Chapter in Comprehensive Coordination Chemistry III Vol. 8, Y. Lu, L. Que, Eds., Elsevier, Oxford, 2021, pp. 968-993. DOI 10.1016/B978-0-08-102688-5.00112-4

DeRose, V.J. and Michel, S. Editorial overview: Bioinorganic chemistry: Metals in biology: approaching the big picture. Current Opinion in Chemical Biology 2020, 55, A4–A6.  DOI 10.1016/j.cbpa.2020.03.002
 
Nucleolar Stress Induction by Oxaliplatin and Derivatives
Emily Sutton*, Christine McDevitt*, Jack Prochnau, Matthew Yglesias, Austin Mroz, Min Chieh Yang, Rachael Cunningham, Christopher Hendon, Victoria J. DeRose,  J. Am. Chem. Soc. 2019 141(46), 18411-18415 Link
 
Monofunctional platinum(II) compounds and nucleolar stress: Is phenanthriplatin unique?
Christine McDevitt, Matthew Yglesias, Austin Mroz, Emily Sutton, Min Chieh Yang, Christopher Hendon, Victoria J. DeRose,  J Biol Inorg Chem. 2019 24(6), 899-906 Link
 
Mapping platinum adducts on yeast ribosomal RNA using high- throughput sequencing
Kory Plakos and Victoria J. DeRose Chem Comm, 2017 53(95), 12746-12749 Link
 
Platinum Binds Proteins in the Endoplasmic Reticulum of S. cerevisiae and Induces Endoplasmic Reticulum Stress
Rachael M. Cunningham and Victoria J. DeRose ACS Chem. Biol., 2017 12(11), 2737-2745 Link
 
Beyond Mg(2+) : functional interactions between RNA and transition metals
Adam M. Saunders and Victoria J. DeRose Curr Opin Chem Biol, 2016 31, 153-159 Link
 
Multifunctional Pt(II) Reagents: Covalent Modifications of Pt Complexes Enable Diverse Structural Variation and In-Cell Detection
Jonathan D. White, Michael M. Haley, and Victoria J. DeRose Acc. Chem. Res., 2016 49(1), 56-66Link
 
Nucleic Acid Catalysis: Metals, Nucleobases, and Other Cofactors
W. Luke Ward, Kory Plakos, and Victoria J. DeRose Chem. Rev. 2013, 135 (32), pp 11680–11683 Link