Profile picture of Marina Guenza

Marina Guenza

Theoretical Physical Chemistry - Structure and Dynamics of Complex Fluids - Novel Computational Methods
Chemistry and Biochemistry, Institute for Fundamental Science
Phone: 541-346-2877
Office: 136 Klamath Hall
Research Interests: Coarse-Graining and Multiscale Modeling, Theoretical Chemistry, Machine Learning


M.S., University of Genoa, Italy, 1985 (Angelo Perico). Ph.D., Consortium of the Universities of Genoa, Turin, and Pavia, Italy, 1989. 1989–99 Tenured Researcher, National Council of Research, Italy. 1994 Visiting Scientist at University of Chicago, James Franck Institute, with Karl F. Freed. 1995–97 Visiting Scientist at University of Illinois at Urbana-Champaign,  with Ken S. Schweizer. 1998-1999 Visiting Scientist, University of Oregon. 2002-2006 Assistant Professor, University of Oregon. 2006-2012 Associate Professor, University of Oregon. 2012 - present, Professor, University of Oregon.

Honors and Awards:
2018 - present, Fellow of the American Association for the Advancement of Science
2015 University of Oregon Interdisciplinary Research Award
2015 University of Oregon Faculty Excellence Award
2011 - present, Fellow of the American Physical Society
2010-2013 Editorial Advisory Board of Macromolecules
1985-1988, Italian Ministry of Public Instruction fellow
Memberships: American Chemical Society, American Physical Society, Biophysical Society, American Association for the Advancement of Science


The Guenza group studies the structure and dynamics of complex macromolecular liquids using equilibrium, non-equilibrium statistical mechanics, and advanced computational methods. For more details see our webpage.


Research Gate Profile

Recent Publications:

M. Dinpajooh, J. Millis, J. Donley, M. G. Guenza "Chemical Potential of a Flexible Polymer Liquid in a Coarse-Grained Representation" The Journal of Physical Chemistry (2023 - accepted) DOI: 10.1021/acs.jpcb.3c06795. 

M.G.Guenza “Dynamics of protein droplets revealed by bridging multiple scales” Nature, 619, 700 (2023).  doi:

M. G. Guenza "Anomalous Dynamics in Macromolecular Liquids" Polymers 14(5), 856 (2022) DOI: 10.3390/polym14050856. 

E. R. Beyerle, M. G. Guenza “Identifying the leading dynamics of ubiquitin: A comparison between the tICA and the LE4PD slow fluctuations in amino acids’ position" J. Chem. Phys. 155, 244108 (1-22) (2021) DOI: 10.1063/5.0059688

E. R. Beyerle, M. G. Guenza “Comparison between slow anisotropic LE4PD fluctuations and the principal component analysis mode of ubiquitin” J. Chem. Phys. 154, 12411(1-21) (2021) DOI: 10.1063/5.0041211 

E. R. Beyerle, M. Dinpajooh, H. Ji, P. H. von Hippel, A. H. Marcus, and M. G. Guenza “Dinucleotides as simple models of the base stacking-unstacking component of DNA ‘breathing’ mechanisms” Nucleic Acid Research, 49(4), 1872-1885 (2021). PMCID: PMC7913701. DOI: 10.1093/nar/gkab015. 

E. R. Beyerle, M. G. Guenza "Kinetics analysis of ubiquitin local fluctuations with Markov state modeling of the LE4PD normal modes” J. Chem. Phys. 151, 164119(1-13) (2019) DOI: 10.1063/1.5123513

M. Dinpajooh, M. G. Guenza “Can pure polymer liquids be represented at two different resolutions simultaneously?" J. Chem. Phys., 151, 061102-(1-5) (2019). DOI: 10.1063/1.5115791. 

M. G. Guenza, M. Dinpajooh, J. McCarty, I. Y. Lyubimov “Accuracy, Transferability, and Efficiency of Coarse-Grained Models of Molecular Liquids” The Journal of Physical Chemistry B, 122(45), 10257-10278 (2018). DOI: 10.1021/acs.jpcb.8b06687. Publication Selected as Editor’s Pick and Feature Article.

M. Dinpajooh, M. G. Guenza “Coarse-graining simulation approaches for polymer melts: the effect of potential range on computational efficiency” Soft Matter, 14, 7126-7144 (2018). Cover paper.

M. Dinpajooh, and M. G. Guenza “On the Density Dependence of the Integral Equation Coarse-Graining Effective Potential" The Journal of Physical Chemistry B, 122(13), 3426-3440 (2018). DOI:10.1021/acs.jpcb.7b10494.

P. G. Romano and M. G. Guenza “GRadient Adaptive Decomposition (GRAD) Method: Optimized Refinement Along Macrostate Borders in Markov State Models" The Journal of Chemical Infromation and Modeling 57, 2729-2740 (2017). 

J. Copperman, M. Dinpajooh, E. Beyerle, and M. G. Guenza “Universality and specificity in protein fluctuation dynamics" Physical Review Letters, 119, 158101 (2017).

M. Dinpajooh, and M. G. Guenza “Thermodynamic Consistency in the Structure-based Integral Equation Coarse-Grained Method" Polymers, 117, 282-286 (2017).

E. deLorimier, M. N. Hinman, J. Copperman, K. Datta, M. Guenza, and J. A. Berglund “Pseudouridine Modification Inhibits Muscleblind-like 1(MBNL1) Binding to CCUG Repeats and Minimally Structured RNA through Reduced RNA Flexibility” Journal of Biological Chemistry, 292, 4350-4357 (2017).

M. G. Guenza "Thermodynamically Consistent Coarse-Graining of Polymers" in "Coarse-Grained Modeling of Biomolecules" (Series in Computational Biophysics by Tylor & Francis Publisher, G. Papoian Ed. 2017) arXiv:1509.08546.